January 11, 2018
The risks and benefits of opioids have been known for decades; however, their consumption has skyrocketed in the U.S. since the late 1990s, fueling a crisis in public health that began garnering major attention in the 2010s. Years in the making, the opioid epidemic now accounts for a majority of all drug overdoses in the country, according to the Centers for Disease Control and Prevention (CDC).
The roots of modern opioid use include the widespread consumption of morphine during the Civil War and the introduction of heroin as a commercial painkiller in the 1890s. Then, following the passage of the Anti-Heroin Act of 1924, opioids were effectively sidelined for decades in response to a general concern among physicians about the perceived addictiveness of similar substances.
Starting with Percocet and Vicodin in the 1970s and then OxyContin in the 1990s, opioid use surged again through widespread legal consumption. By 2012, U.S. physicians wrote 282 million opioid prescriptions annually, up from 112 million in 1992, according to IMS Health. Prescriptions jumped by 11 million between 1998 and 1999 alone, following a pivotal video testimonial about the benefits of oxycodone for pain relief.
On the one hand, opioids fill an important medical niche in pain management. For example, fentanyl - one of the most potent opioids - is included on the World Health Organization's List of Essential Medicines. On the other, their rising usage over time does not correspond to an uptick in reported pain by patients and has had serious consequences for their health:
The vast extent of the opioid crisis has inspired action from governments, healthcare providers and the public at-large. For example, the White House declared it a health emergency in October 2017. While much attention to the problem has been on the federal reaction, some of the most substantial responses have been initiated at the state and local levels.
In early 2017, New Jersey passed one of the nation's most restrictive laws for opioid prescribing. The legislation limits the prescribed opioid supply for acute pain treatment, even for postoperative pain, to only 5 days at the lowest effective dosage. This timeline is shorter than the already-strict 7 days allowed by New York and Massachusetts, a legal limit designed to match CDC recommendations. Overall, 10 states had such laws on the books as of November 2017.
CDC guidance goes beyond reactive strategies such as MAT, and recommends proactive prescription of non-opioid alternatives whenever feasible. Many well-known drugs fit into this category, including acetaminophen, ibuprofen, and some antidepressants and anticonvulsants. Other treatment possibilities include exercise and physical therapy, cognitive behavior therapy and injections/interventional treatments.
Many non-opioid analgesics are also in the pipeline and may provide appealing options in the future. Meanwhile, hospitals and first responders have continued seeking ways to reduce opioid volume. Success requires thorough consideration of all available treatments and how they impact patient health and overall system costs. A trusted provider of drug utilization review can be an asset throughout this process.
Healthcare institutions are taking steps to address the opioid crisis with new policies and opioid prescription reduction goals. The Intermountain Healthcare hospital chain committed itself this year to lowering its opioid prescriptions by 40 percent by the end of 2018. The Veterans Administration achieved a similar reduction at several test sites in 2016 and has explored opioid alternatives like acupuncture and the Pain Coach mobile app.
At Advanced Medical Reviews (AMR), an independent review organization, drug utilization reviews (DUR) offer an ongoing review of how providers prescribe based on evidence-based guidelines. As Dan Perlow, VP Strategic Partnerships at AMR, explains, "At AMR, cases are frequently referred to review everything from medical necessity of drugs to potential interaction of multiple medication and fraud investigation. Whether a prospective, concurrent, or retrospective review, DUR is an ideal tool for ensuring appropriate provider prescription behavior and positive patient outcomes from opioid use."
Looking ahead to 2018 and beyond, we can expect further commitment by providers and payments to more appropriate use of opioids along with increased deference to other medications and procedures. These efforts follow the heightened national awareness of the issue in the wake of numerous viral news stories. We will explore how physicians are responding to new public demands for action on opioids in subsequent posts.
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